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BPS Pharmacotherapy (Part1 and Part2) Sample Questions:

1. A 38-year-old man with stage II testicular cancer has received a 5-day course of Cisplatin and etoposide, followed by daily Filgrastim. On day 14, he reports duki aching bone pain. Which of the following is the most likely cause of this complaint?

A) Cisplatin
B) Etoposide
C) Disease progression
D) Filgrastim

2. For a 34-year-old Woman with a history of ethanol abuse, cirrhosis, ascites, and jaundice, which of the following is the most important factor predisposing her to hepatorenal syndrome?

A) Hypokalemia
B) Metabolic acidosis
C) Volume depletion
D) Hypocalcaemia

3. A 42-year-old woman is diagnosed with deep vein thrombosis. Heparin therapy is initiated with
5,000 units as a single bolus injection, followed by an initial infusion rate of 1,000 units/h. The aPTT measured 6 hours later is >150 sec. Which of the following would be the most appropriate action at this time?

A) Administer protamine 5 mg, and decrease the infusion rate to 750 units/h.
B) Continue the infusion at 1,000 units/h, since the aPTT was drawn too early and is not useful.
C) Stop the infusion until the aPTT falls to <50 sec, and then resume at 750 units/h.
D) Stop the infusion for one hour, then resume at 750 units/h.

4. A clinical trial is being designed to evaluate the efficacy of an intermediate-acting niacin preparation in a population with regard to amelioration of coronary artery disease risk.
Bioethical considerations would restrict recruitment of subjects with poorly controlled diabetes mellitus, recent gastroduodenal ulcer disease, or hyperuricemia. Which principle would consider these patients to be ineligible for enrollment?

A) Equipoise
B) Justice
C) Autonomy
D) Beneficence

5. A pharmacotherapy specialist is the anticoagulation clinic manager at a for-profit institution.
One of the internal medicine physicians in this institution is interested in submitting a research grant application to the National Institutes of Health (NIH) to study the effectiveness of low- intensity warfarin therapy on prevention of recurrent venous thromboembolism in patients.
This was the subject of the PREVENT trial.
With regard to the grant application, the pharmacotherapy specialist should inform the physician about which of the following restrictions?

A) NIH-funded research can take place only on the campus.
B) The NIH funds only studies involving drugs that have not yet been FDA-approved.
C) The NIH funds only novel research.
D) The NIH provides grants only to nonprofit organizations.

Solutions: